A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
- 3 July 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 43 (8), 792-796
- https://doi.org/10.1038/ng.875
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a genome-wide association scan in 5,408 subjects (2,331 individuals with lung cancer (cases) and 3,077 controls) followed by a two-stage validation among 12,722 subjects (6,313 cases and 6,409 controls). The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10−8) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10−26), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10−20 and P = 1.0 × 10−27, respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10−12) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10−11 and P = 6.2 × 10−13, respectively). Two of these loci (13q12.12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.Keywords
This publication has 28 references indexed in Scilit:
- Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3Nature Genetics, 2010
- Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populationsNature Genetics, 2010
- A functional variant (−1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activityCarcinogenesis: Integrative Cancer Research, 2010
- A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility lociNature Genetics, 2010
- Functional Promoter −1271G>C Variant of HSPB1 Predicts Lung Cancer Risk and SurvivalJournal of Clinical Oncology, 2010
- STATs in cancer inflammation and immunity: a leading role for STAT3Nature Reviews Cancer, 2009
- Common 5p15.33 and 6p21.33 variants influence lung cancer riskNature Genetics, 2008
- Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Nature Genetics, 2008
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006
- TAJ, a Novel Member of the Tumor Necrosis Factor Receptor Family, Activates the c-Jun N-terminal Kinase Pathway and Mediates Caspase-independent Cell DeathPublished by Elsevier BV ,2000