A controlled trial of recombinant methionyl human BDNF in ALS
- 1 April 1999
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 52 (7), 1427
- https://doi.org/10.1212/wnl.52.7.1427
Abstract
Objective: To replicate the beneficial effect of brain-derived neurotrophic factor (BDNF) in 1,135 ALS patients in a multicenter trial.Keywords
This publication has 18 references indexed in Scilit:
- Works in progress abstractsAnnals of Neurology, 1995
- A multiple imputation strategy for clinical trials with truncation of patient dataStatistics in Medicine, 1995
- Effects of brain‐derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron diseaseAnnals of Neurology, 1995
- Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNFScience, 1994
- Increased trkB mRNA expression by axotomized motoneuronesNeuroReport, 1994
- Neurotrophins promote motor neuron survival and are present in embryonic limb budNature, 1993
- Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivoNeuron, 1993
- Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve sectionNature, 1992
- Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell deathNature, 1992
- Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.The Journal of cell biology, 1992