9‐cis β‐carotene in human plasma and blood cells after ingestion of β‐carotene
- 1 June 1995
- Vol. 30 (6), 493-498
- https://doi.org/10.1007/bf02537022
Abstract
For 44 wk, thirty male volunteers were given daily either 60 mg of synthesized all-trans β-carotene, a naturally-occurring β-carotene derived fromDunaliella bardawil, or a placebo. Basal levels of 9-cis β-carotene in plasma, platelets, and mononuclear cells were 10, 20 and 25% of those of the all-trans form, respectively. The plasma levels reached a maximum after two weeks of administration and plateaued thereafter in the subjects who took the β-carotene preparations. The all-trans β-carotene level in the subjects given the synthesized all-trans form was almost twice that for theDunaliella preparation. The plasma 9-cis level was found to be higher in the all-trans β-carotene group than in theDunaliella group, despite no intake of the 9-cis form in the all-trans group and the higher intake of the 9-cis form in theDunaliella group. This finding suggests that isomerization of the all-trans form to the 9-cis form may occur in the body either during or after absorption.Keywords
This publication has 12 references indexed in Scilit:
- Bioavailability of β‐ Carotene in a Carotenoid Preparation Derived from Dunaliella bardawil in Human Male AdultsAnnals of the New York Academy of Sciences, 1993
- Separation of beta-carotene and lycopene geometrical isomers in biological samplesClinical Chemistry, 1993
- Human Serum Concentrations of all-trans β- and α-Carotene but Not 9-cis β-Carotene Increase upon Ingestion of a Natural Isomer Mixture Obtained from Dunaliella salina (Betatene)Journal of Nutrition, 1993
- Determination of β-carotene in plasma, blood cells and buccal mucosa by electrochemical detectionLipids, 1992
- cis-trans isomers of lycopene and β-carotene in human serum and tissuesArchives of Biochemistry and Biophysics, 1992
- An improved HPLC Method for the Separation of Fourteen Carotenoids, Including 15-/13- and 9-CIS-β-Carotene Isomers, Phytoene and PhytoflueneJournal of Liquid Chromatography, 1991
- Structural and Geometrical Isomers of Carotenoids in Human PlasmaJournal of Nutrition, 1990
- Determination of beta-carotene and its cis isomers in serumClinical Chemistry, 1990
- Bioavailability of a Natural Isomer Mixture as Compared with Synthetic all-trans-β-Carotene in Rats and ChicksJournal of Nutrition, 1989
- A Review of Epidemiologic Evidence that Carotenoids Reduce the Risk of CancerJournal of Nutrition, 1989