Functional organization of variola major and vaccinia virus genomes
- 1 February 1995
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virus Genes
- Vol. 10 (1), 53-71
- https://doi.org/10.1007/bf01724297
Abstract
Comparison of the genomic organization of variola and vaccinia viruses has been carried out. Molecular factors of virulence of these viruses is the focus of this review. Possible roles of the genes of soluble cytokine receptors, complement control proteins, factors of virus replication, and dissemination in vivo for variola virus pathogenesis are discussed. The existence of “buffer” genes in the vaccinia virus genome is proposed.Keywords
This publication has 350 references indexed in Scilit:
- Analysis of the nucleotide sequence of 48 kbp of the variola major virus strain India-1967 located on the right terminus of the conservative genome regionVirus Research, 1994
- Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strainVirus Research, 1993
- Comparative analysis of the conserved region of the orthopoxvirus genome encoding the 36K and 12K proteinsVirus Research, 1993
- Comparison of the genetic maps of variola and vaccinia virusesFEBS Letters, 1993
- The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproductionVirus Research, 1993
- Gene A32 product of vaccinia virus may be an ATPase involved in viral DNA packaging as indicated by sequence comparisons with other putative viral ATPasesVirus Genes, 1993
- Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragmentsVirus Research, 1993
- Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activitiesVirology, 1991
- Fine structure of the vaccinia virus gene encoding the precursor of the major core protein 4 aArchiv für die gesamte Virusforschung, 1988
- The role of the host cell nucleus in vaccinia virus morphogenesisVirus Research, 1987