Glycosaminoglycans in normal and osteoarthrotic human temporomandibular joint disks
- 1 January 1992
- journal article
- research article
- Published by Informa UK Limited in Acta Odontologica Scandinavica
- Vol. 50 (2), 113-119
- https://doi.org/10.3109/00016359209012753
Abstract
Glycosaminoglycans in normal and osteoarthrotic temporomandibular joint disks were studied by means of high-performance liquid chromatography methods. Normal disk tissue contains galactosaminoglycans (chondroitin sulfate and dermatan sulfate) as the main polysaccharides and with smaller amounts of hyaluronate and heparan sulfate. The galactosaminoglycans are mainly sulfated in 6-position, and some of the disaccharides contain iduronic acid. There was a slight general variation in glycosaminoglycan concentration with increasing age. In the severely arthrotic disks the content of glycosaminoglycans was considerably lower than in normal disk tissue. This decrease was far more extensive than that observed in relation to age in normal tissue. The 4/6-sulfate ratio of the galactosaminoglycans was increased, whereas the proportion of iduronic acid was markedly decreased. □ High-performance liquid chromatography; polysaccharidesKeywords
This publication has 23 references indexed in Scilit:
- Measurement of sulphated glycosaminoglycans and proteoglycan fragments in arthritic synovial fluid.Annals Of The Rheumatic Diseases, 1989
- Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. relation to systemic treatmentArthritis & Rheumatism, 1987
- Remodeling of the Temporomandibular Joint Disk and Posterior Attachment in Disk Displacement Specimens in Relation to Glycosaminoglycan ContentPlastic and Reconstructive Surgery, 1986
- Separation and quantitative determination of galactosamine and glucosamine at the nanogram level by sulphonyl chloride reaction and high-performance liquid chromatographyJournal of Chromatography A, 1980
- Constitutional Variations of Acidic Glycosaminoglycans in Normal and Arthritic BO Vine Articular Cartilage Proteoglycans at Different AgesConnective Tissue Research, 1980
- Determination of sulphated disaccharides from chondroitin suphates by high-performance liquid chromatographyJournal of Chromatography A, 1979
- Topographical distribution of sulphated glycosaminoglycans in human temporomandibular joint disksJournal of Oral Pathology & Medicine, 1976
- The Glycosaminoglycans of Normal and Arthritic CartilageJCI Insight, 1971
- Fractionation and quantitative determination of keratan sulfate using cetylpyridinium chloride and ECTEOLA - celluloseBiochimica et Biophysica Acta (BBA) - General Subjects, 1970