Long-term exposure to duodenal levodopa/carbidopa infusion therapy improves quality of life in relation especially to mobility, activities of daily living, and emotional well-being
- 26 May 2011
- journal article
- clinical trial
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 125 (3), 187-191
- https://doi.org/10.1111/j.1600-0404.2011.01523.x
Abstract
Continuous duodenal levodopa infusion (DLI) is an effective therapy that improves quality of life (QoL) in advanced Parkinson's disease (PD). However, in which aspects improve the patients their QoL has been poorly documented. We evaluated 39-item Parkinson's disease Quality of Life Questionnaire Summary Index score (PDQ-39SI) changes analyzing its different domains in nine patients with advanced PD treated with DLI. All the patients (64.7 ± 11.1 years, 55.5% men) improved PDQ-39SI 6 months after beginning with DLI (29.7 ± 8.6, P = 0.008) and after median duration infusion of 25.3 ± 8.8 months (34.8 ± 11.2, P = 0.008) compared with baseline (55.6 ± 11.5). All domains except social support improved significantly at 6 months. Mobility (P = 0.012), activities of daily living (P = 0.015), and emotional well-being (P = 0.008) improved significantly at the end of the follow-up. DLI improves QoL in patients with advanced PD after short- and long-term exposure. Whereas all domains except social support improve after 6 months under DLI, only mobility, activities of daily living and emotional well-being improve significantly after long-term exposure to DLI.Keywords
This publication has 14 references indexed in Scilit:
- Experiencia con la infusión continua de levodopa intraduodenal (Duodopa®) en pacientes con enfermedad de Parkinson avanzada en un hospital de segundo nivel asistencialNeurología, 2010
- Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson's disease: Impact on control of fluctuations and quality of lifeParkinsonism & Related Disorders, 2010
- Suicide following duodenal levodopa infusion for Parkinson's diseaseMovement Disorders, 2009
- Intrajejunal levodopa infusion in Parkinson's disease: A pilot multicenter study of effects on nonmotor symptoms and quality of lifeMovement Disorders, 2009
- Comparison of apomorphine and levodopa infusions in four patients with Parkinson’s disease with symptom fluctuationsActa Neurologica Scandinavica, 2009
- Continuous dopaminergic stimulation achieved by duodenal levodopa infusionNeurological Sciences, 2008
- Duodenal Levodopa Infusion Improves Quality of Life in Advanced Parkinson’s DiseaseNeurodegenerative Diseases, 2008
- Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcomeMovement Disorders, 2007
- Outcome prediction of enteral levodopa/carbidopa infusion in advanced Parkinson's diseaseParkinsonism & Related Disorders, 2006
- Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson diseaseNeurology, 2005