Consanguineous unions and the burden of disability: A population‐based study in communities of Northeastern Brazil
- 5 October 2012
- journal article
- research article
- Published by Wiley in American Journal of Human Biology
- Vol. 24 (6), 835-840
- https://doi.org/10.1002/ajhb.22328
Abstract
Objectives: The aim of this study was to identify communities at high risk of transmitting recessive genetic disorders by measuring levels of endogamy and offspring's rate of disabilities. Methods: In a house-to-house population based-survey in the state of Paraíba, 20,462 couples were interviewed regarding kinship relation, number of siblings and offspring affected by mental or physical disabilities. Results: The rate of consanguineous unions in the communities ranged from 6.0% to 41.14%, showing an average value of 20.19% ± 9.13%. The overall average inbreeding coefficient (F) was 0.00602 ± 0.00253, ranging from 0.00134 to 0.01182. Communities situated on the backlands had an increased average value of F compared to those closer to the seashore (P = 0.024). The average rate of disabled offspring varied from 2.96% ± 0.68% for unrelated unions to 10.44% ± 16.86% for related couples at the level of double first cousins or uncle–niece. The Spearman correlation coefficient between the overall rate of disabled offspring from all couples together and F was 0.510 (P < 0.01). Conclusion: Inbreeding increases the risk of disability which is unevenly distributed, varying considerably even in neighboring communities with similar Human Development Index and population density. Higher inbreeding communities are mostly located on the more economically underdeveloped backlands than on the coastal region. The identification of communities at high risk for genetic disorders could serve as basis for the establishment of Community Genetics programs. Am. J. Hum. Biol., 2012.Keywords
This publication has 24 references indexed in Scilit:
- Four chapters in the history of crypto-Judaism in Brazil: the case of the northeastern New Christians (17th–21st centuries)Jewish History, 2010
- THE EFFECT OF CONSANGUINITY ON CONGENITAL DISABILITIES IN THE KUWAITI POPULATIONJournal of Biosocial Science, 2010
- Consanguinity, human evolution, and complex diseasesProceedings of the National Academy of Sciences of the United States of America, 2010
- Hearing Loss: Mechanisms Revealed by Genetics and Cell BiologyAnnual Review of Genetics, 2008
- Consanguinity and major genetic disorders in Saudi children : A community-based cross-sectional studyAnnals of Saudi Medicine, 2008
- Association of parental consanguinity with congenital malformations among Arab newborns in JerusalemClinical Genetics, 2004
- Human and medical genetics in BrazilGenetics and Molecular Biology, 2000
- The Role and Significance of Consanguinity as a Demographic VariablePopulation and Development Review, 1994
- Reproductive Behavior and Health in Consanguineous MarriagesScience, 1991
- Further data on inbreeding levels in Brazilian populationsSocial Biology, 1970