Comparison of Quantitative Autoradiographic and Xenon-133 Clearance Methods: Correlation of Gray and White Matter Cerebral Blood Flow with Compartmental Blood Flow Indices
Open Access
- 1 August 1986
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 6 (4), 481-485
- https://doi.org/10.1038/jcbfm.1986.82
Abstract
The relationships between CBF in gray and white matter to those of the fast and slow components of xenon-133 clearance curves remain uncertain. CBF was measured in 13 anaesthetized baboons under a variety of conditions, using both the xenon-133 clearance technique and [14C]iodoantipyrine quantitative autoradiography. There was a linear relationship between CBF, as determined by the stochastic (height/area) analysis of the clearance curve, and mean CBF determined from the autoradiograms ( r = 0.94, p < 0.001, slope = 0.86 ± 0.09). There was also a linear correlation between the fast-flow component (measured with xenon-133) and blood flow in the cerebral gray matter (measured with [14C]iodoantipyrine) ( r = 0.92, p < 0.001, slope = 0.69 ± 0.15) and between the slow-flow component (with xenon-133) and blood flow in white matter (with [14C]iodoantipyrine) ( r = 0.79, p < 0.01, slope = 0.81 ± 0.10). In the primate brain, the fast- and slow-flow indices therefore appear to be representative of CBF in gray matter and white matter, respectively, whereas the stochastic analysis provides a stable measure of mean CBF within the tissue monitored.Keywords
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