Stillbirth and Fetal Growth Restriction
- 1 September 2010
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Obstetrics and Gynecology
- Vol. 53 (3), 673-680
- https://doi.org/10.1097/grf.0b013e3181eba0db
Abstract
The association between stillbirth and fetal growth restriction is strong and supported by a large body of evidence and clinically employed for the stillbirth prediction. However, although assessment of fetal growth is a basis of clinical practice, it is not trivial. Essentially, fetal growth is a result of the genetic growth potential of the fetus and placental function. The growth potential is the driving force of fetal growth, whereas the placenta as the sole source of nutrients and oxygen might become the rate limiting element of fetal growth if its function is impaired. Thus, placental dysfunction may prevent the fetus from reaching its full genetically determined growth potential. In this sense fetal growth and its aberration provides an insight into placental function. Fetal growth is a proxy for the test of the effectiveness of placenta, whose function is otherwise obscured during pregnancy.Keywords
This publication has 27 references indexed in Scilit:
- Stillbirth Classification—Developing an International Consensus for ResearchObstetrics & Gynecology, 2009
- StillbirthThe Lancet, 2007
- Circulating Angiogenic Factors in Early Pregnancy and the Risk of Preeclampsia, Intrauterine Growth Restriction, Spontaneous Preterm Birth, and StillbirthObstetrics & Gynecology, 2007
- Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal deathBJOG: An International Journal of Obstetrics and Gynaecology, 2007
- Reconciling the High Rates of Preterm and Postterm Birth in the United StatesObstetrics & Gynecology, 2007
- Maternal Uterine Artery Doppler Flow Velocimetry and the Risk of StillbirthObstetrics & Gynecology, 2007
- First-Trimester Placentation and the Risk of Antepartum StillbirthJAMA, 2004
- Qualitative venous Doppler waveform analysis improves prediction of critical perinatal outcomes in premature growth‐restricted fetusesUltrasound in Obstetrics & Gynecology, 2003
- Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous treeAmerican Journal of Obstetrics and Gynecology, 1996
- A united states national reference for fetal growthObstetrics & Gynecology, 1996