Photoacoustic tomography of biological tissues with high cross‐section resolution: Reconstruction and experiment
- 27 November 2002
- journal article
- Published by Wiley in Medical Physics
- Vol. 29 (12), 2799-2805
- https://doi.org/10.1118/1.1521720
Abstract
A modified back-projection approach deduced from an exact reconstruction solution was applied to our photoacoustictomography of the optical absorption in biological tissues. Pulses from a Ti:sapphire laser (4.7 ns FWHM at 789.2 nm) were employed to generate a distribution of photoacoustic sources in a sample. The sources were detected by a wide-band nonfocused ultrasonic transducer at different positions around the imaging cross section perpendicular to the axis of the laser irradiation. Reconstructed images of phantoms made from chicken breast tissue agreed well with the structures of the samples. The resolution in the imaging cross section was experimentally demonstrated to be better than 60 μm when a 10 MHz transducer (140% bandwidth at −60 dB) was employed, which was nearly diffraction limited by the detectable photoacoustic waves of the highest frequency.Keywords
Funding Information
- Medical Research and Materiel Command (DAMD 17‐00‐1‐0455)
- National Institutes of Health (R01 CA71980)
- National Science Foundation (BES‐9734491)
- Texas Higher Education Coordinating Board (ARP 000512‐0123‐1999)
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