Translating molecular discoveries into new therapies for atherosclerosis
Top Cited Papers
- 20 February 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 451 (7181), 904-913
- https://doi.org/10.1038/nature06796
Abstract
Atherosclerosis is characterized by the thickening of the arterial wall and is the primary cause of coronary artery disease and cerebrovascular disease, two of the most common causes of illness and death worldwide. Clinical trials have confirmed that certain lipoproteins and the renin–angiotensin–aldosterone system are important in the pathogenesis of atherosclerotic cardiovascular disease, and that interventions targeted towards these are beneficial. Furthermore, efforts to understand how risk factors such as high blood pressure, dysregulated blood lipids and diabetes contribute to atherosclerotic disease, as well as to understand the molecular pathogenesis of atherosclerotic plaques, are leading to new targets for therapy.Keywords
This publication has 98 references indexed in Scilit:
- Mouse Models for Atherosclerosis and Pharmaceutical ModifiersArteriosclerosis, Thrombosis, and Vascular Biology, 2007
- Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication StudyJama-Journal Of The American Medical Association, 2007
- LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk FactorsScience, 2007
- Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9Proceedings of the National Academy of Sciences of the United States of America, 2005
- NARC-1/PCSK9 and Its Natural MutantsPublished by Elsevier BV ,2004
- Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed miceJournal of Lipid Research, 2003
- Mutations in PCSK9 cause autosomal dominant hypercholesterolemiaNature Genetics, 2003
- Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor ProteinScience, 2001
- AtherosclerosisNature, 2000
- Natural History and Histological Classification of Atherosclerotic LesionsArteriosclerosis, Thrombosis, and Vascular Biology, 2000