Age-dependent alteration of TGF-β signalling in osteoarthritis
Open Access
- 4 June 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 347 (1), 257-265
- https://doi.org/10.1007/s00441-011-1194-6
Abstract
Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-β has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced Smad2/3 phosphorylation, but also via ALK1-induced Smad1/5/8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1/ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.Keywords
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