Effects of Hypothermia on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats
Open Access
- 1 September 2003
- journal article
- research article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 10 (5), 940-943
- https://doi.org/10.1128/cdli.10.5.940-943.2003
Abstract
We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.Keywords
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