Structure of human factor VIII
- 1 November 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 312 (5992), 337-342
- https://doi.org/10.1038/312337a0
Abstract
The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.Keywords
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