Quantitative comparison of the histological effects of particulate polymethylmethacrylate versus polyethylene in the rabbit tibia
- 1 April 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archives of orthopaedic and trauma surgery
- Vol. 110 (3), 123-126
- https://doi.org/10.1007/bf00395792
Abstract
Fourteen mature female New Zealand White rabbits underwent implantation of Simplex polymethylmethacrylate (PMMA) powder or particulate (average 67 μn) ultrahigh-molecular-weight polyethylene (UHMWPE) through a drill hole in the proximal right tibia. The left tibia functioned as a prepared but nonimplanted control. Animals were killed after 16 weeks. Histological examination of the bone-implant interface in the particulate PMMA group disclosed a florid foreign-body reaction with the presence of giant cells and histiocytes. The particulate UHMWPE group demonstrated positively bire-fringent UHMWPE fragments, rimmed by foreign-body giant cells and histiocytes, embedded in a loose connective tissue stroma. UHMWPE interfaces were thicker and contained more histiocytes and fibrocytes; PMMA interfaces contained more marrow cells and lymphocytes. This study underscores the importance of biomaterial debris in the process of aseptic loosening of cemented joint arthroplasties.Keywords
This publication has 32 references indexed in Scilit:
- The Effects of Bulk Versus Particulate Polymethylmethacrylate on BoneClinical Orthopaedics and Related Research, 1988
- Foreign Body Reaction to Polymeric Debris Following Total Hip ArthroplastyClinical Orthopaedics and Related Research, 1987
- Formation of a synovial‐like membrane at the bone‐cement interface: Its role in bone resorption and implant loosening after total hip replacementArthritis & Rheumatism, 1986
- Aseptic Loosening of Hip Prostheses A Histologic and Enzyme Histochemical StudyClinical Orthopaedics and Related Research, 1983
- Tissue response to carbon‐reinforced polyethyleneJournal of Orthopaedic Research, 1983
- The Pathology of Failed Total Joint ArthroplastyClinical Orthopaedics and Related Research, 1982
- Revision of Aseptic Loose Total Hip ArthroplastiesClinical Orthopaedics and Related Research, 1982
- Wear mechanisms for ultrahigh molecular weight polyethylene in the total hip prosthesisJournal of Applied Polymer Science, 1979
- Evaluation of the Tissue Response to the Wear Products of the Hip Joint Endo-ArthroprosthesisBiomaterials, Medical Devices, and Artificial Organs, 1979
- The appearances of wear on polyethylene?a comparison ofin vivo andin vitro wear surfacesJournal of Biomedical Materials Research, 1978