Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
Open Access
- 1 November 2013
- journal article
- Published by Elsevier BV
- Vol. 288 (46), 33027-33036
- https://doi.org/10.1074/jbc.m113.517540
Abstract
No abstract availableKeywords
This publication has 49 references indexed in Scilit:
- Linking lipids to Alzheimer's disease: cholesterol and beyondNature Reviews Neuroscience, 2011
- Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and DiseaseAnnual Review of Cell and Developmental Biology, 2010
- Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross TalkCold Spring Harbor Perspectives in Biology, 2010
- Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's DiseaseASN Neuro, 2010
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1Science Signaling, 2010
- Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammationBrain, 2008
- Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolismProceedings of the National Academy of Sciences of the United States of America, 2006
- PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2JCI Insight, 2006
- Production of Soluble Triggering Receptor Expressed on Myeloid Cells by Lipopolysaccharide-Stimulated Human Neutrophils Involves De Novo Protein SynthesisClinical and Vaccine Immunology, 2006
- TREMs in the immune system and beyondNature Reviews Immunology, 2003