Current and future directions of deep brain stimulation for neurological and psychiatric disorders
- 31 July 2019
- journal article
- review article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 131 (2), 333-342
- https://doi.org/10.3171/2019.4.JNS181761
Abstract
Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it has primarily been used to treat movement disorders such as Parkinson's disease, essential tremor, and dystonia, recently it has been approved to treat obsessive-compulsive disorder and epilepsy. Novel potential indications in both neurological and psychiatric disorders are undergoing active study. There have been significant advances in DBS technology, including preoperative and intraoperative imaging, surgical approaches and techniques, and device improvements. In addition to providing significant clinical benefits and improving quality of life, DBS has also increased the understanding of human electrophysiology and network interactions. Despite the value of DBS, future developments should be aimed at developing less invasive techniques and attaining not just symptom improvement but curative disease modification.This publication has 84 references indexed in Scilit:
- Motor cortex stimulation for facial chronic neuropathic pain: A review of the literatureSurgical Neurology International, 2012
- Beyond faithful conduction: Short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axonProgress in Neurobiology, 2011
- The Subthalamic Nucleus becomes a Generator of Bursts in the Dopamine-Depleted State. Its High Frequency Stimulation Dramatically Weakens Transmission to the Globus PallidusFrontiers in Systems Neuroscience, 2011
- Dynamic Stereotypic Responses of Basal Ganglia Neurons to Subthalamic Nucleus High-Frequency Stimulation in the Parkinsonian PrimateFrontiers in Systems Neuroscience, 2011
- Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC)Neuroscience, 2010
- Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s diseaseBrain, 2010
- Functional Alterations in Memory Networks in Early Alzheimer’s DiseaseNeuroMolecular Medicine, 2010
- Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?Journal of Neurology, Neurosurgery & Psychiatry, 2007
- Stereotactic Limbic Leucotomy—A Follow-up at 16 MonthsThe British Journal of Psychiatry, 1976
- Chemopallidectomy: An Investigative Technique in Geriatric ParkinsoniansScience, 1955