Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A
- 17 December 2012
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in MedChemComm
- Vol. 4 (2), 443-449
- https://doi.org/10.1039/c2md20239e
Abstract
Twenty eight new analogues were synthesized by optimizing the structure of MP-10 and their in vitro binding affinities towards PDE10A, PDE3A/B, and PDE4A/B were determined. Among these new analogues, 10a, 10b, 10d, 11a, 11b and 11d are very potent towards PDE10A and have IC50 values of 0.40 ± 0.02, 0.28 ± 0.06, 1.82 ± 0.25, 0.24 ± 0.05, 0.36 ± 0.03 and 1.78 ± 0.03 nM respectively; these six compounds displayed high selectivity for PDE10A versus PDE3A/3B/4A/4B. The promising compounds will be further validated in vivo to identify PDE10A imaging tracers.Keywords
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