Calculating prevalence of hepatitis B in India: Using population weights to look for publication bias in conventional meta-analysis
- 1 December 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Indian Journal of Pediatrics
- Vol. 76 (12), 1247-1257
- https://doi.org/10.1007/s12098-009-0246-3
Abstract
Publication bias can result from the propensity of researchers to document what is unusual. This can distort the inferences drawn in systematic reviews. To measure the distortion, it has been suggested that a second analysis be done; using weights proportional to the size of the population from which the samples are drawn. We re-evaluate data from a published meta-analysis on prevalence of hepatitis B in India, to see how this approach alters the results. Prevalence of hepatitis B among tribal and non-tribal populations in different States was analyzed. Weights were then assigned according to population of the State. The overall country prevalence was then calculated. Using population-weights it is estimated that the point-prevalence of hepatitis B among non-tribal populations is 3.07% [95% CI: 2.5–3.64]. Among tribal populations it is 11.85% (CI 10.76–12.93). Overall prevalence was 3.70 (CI: 3.17–4.24) (corresponding to a chronic carrier rate of 2.96%). The present analysis using population-weights has resulted in the estimated prevalence among non tribal populations increasing by 24% and that among tribal populations decreasing by 25.5% when compared to figures of the meta-analysis published earlier. The advantages and drawbacks of this procedure are discussed.Keywords
This publication has 57 references indexed in Scilit:
- Genotype, phylogenetic analysis, and transmission pattern of occult hepatitis B virus (HBV) infection in families of asymptomatic HBsAg carriersJournal of Medical Virology, 2005
- A Study on the Perinatal Transmission of the Hepatitis B VirusIndian Journal of Medical Microbiology, 2005
- Hepatitis B vaccination in a hyper-endemic tribal community from India: assessment after three yearsVaccine, 2004
- Seroepidemiology of hepatitis B infection among tribal school children in Andaman and Nicobar Islands, IndiaPaediatrics and International Child Health, 2004
- Hepatitis B virus infection in pregnant women and its transmission to infantsJournal of Tropical Pediatrics, 1996
- Detection of HIV‐1, HBV and HCV Antibodies in Blood Donors from Surat, Western IndiaVox Sanguinis, 1994
- A dipstick immunobinding enzyme-linked immunosorbent assay for serodiagnosis of hepatitis B and delta virus infectionsJournal of Virological Methods, 1992
- Comparative evaluation of the immunogenicity of yeast‐derived (recombinant) and plasma‐derived hepatitis B vaccine in infantsJournal of Medical Virology, 1991
- Prevalence of hepatitis B surface antigen in pregnant mothers and its perinatal transmissionTransactions of the Royal Society of Tropical Medicine and Hygiene, 1989
- Dynamics and impact of perinatal transmission of hepatitis B virus in North IndiaJournal of Medical Virology, 1987