Isolation and initial characterization of the mouse Dnmt3l gene

2 April 2001

journal article
animal cytogenetics-and-comparative-mapping
Published by S. Karger AG in Cytogenetic and Genome Research

Vol. 92 (1-2), 122-126
https://doi.org/10.1159/000056881

Abstract

We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cytosine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarity to members of the DNMT3/Dnmt3 family. The Dnmt3l protein contains an ADD zinc finger, which Dnmt3l shares with other Dnmt3 family members and Atrx. RT-PCR analysis showed Dnmt3l expression in testis, thymus, ovary, and heart, as well as in 7-day, 15-day, and 17-day mouse embryos.

Keywords

CYTOGENETICS AND CELL GENETICS 2001
VOL. 92
NO. 1-2
228253

This publication has 2 references indexed in Scilit:

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Cell, 1999
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Cell, 1992

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