Efficacy and safety of rituximab in adults' warm antibody autoimmune haemolytic anemia: Retrospective analysis of 27 cases
- 5 January 2009
- journal article
- clinical trial
- Published by Wiley in American Journal of Hematology
- Vol. 84 (3), 153-157
- https://doi.org/10.1002/ajh.21341
Abstract
To better assess the efficacy and safety of rituximab in adults' warm antibody autoimmune hemolytic anemia (wAIHA), we conducted a retrospective study including 27 adults (mean age 49.7 ± 21 years) with either primary (n = 17) or secondary (n = 10) wAIHA. On average, the patients received 2.1 ± 1.4 treatment lines before rituximab and six had undergone splenectomy. Five patients were resistant to corticosteroids, 16 had a corticosteroid‐dependent wAIHA and six had relapsed after an initial remission. Overall, 25/27 (93%) patients achieved an initial response from rituximab (eight complete responses and 17 partial responses). During a mean follow‐up of 20.9 months after rituximab, five of the responders relapsed, three of whom were successfully retreated with rituximab. Two mild infusion‐related‐reactions occurred, one patient had a rituximab‐related severe neutropenia and one case of pneumocystis jiroveci pneumonia occurred in a severely immunocompromized patient. In conclusion, rituximab seems highly effective and relatively safe in adults with steroid‐resistant or steroid‐dependent wAIHA. Am. J. Hematol. 2009.Keywords
This publication has 25 references indexed in Scilit:
- Attenuated doses of rituximab for the treatment of adults with autoimmune cytopeniasAmerican Journal of Hematology, 2008
- Fatal Pneumocystis pneumonia following rituximab administration for rheumatoid arthritisRheumatology, 2008
- Hemolytic anemia due to warm autoantibodiesBlood Reviews, 2008
- Rituximab for rheumatoid arthritis refractory to anti–tumor necrosis factor therapy: Results of a multicenter, randomized, double‐blind, placebo‐controlled, phase III trial evaluating primary efficacy and safety at twenty‐four weeksArthritis & Rheumatism, 2006
- The efficacy and safety of B‐cell depletion with anti‐CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpuraBritish Journal of Haematology, 2004
- Rituximab for Immune Cytopenia in Adults: Idiopathic Thrombocytopenic Purpura, Autoimmune Hemolytic Anemia, and Evans SyndromeMayo Clinic Proceedings, 2003
- Rituximab for the treatment of refractory autoimmune hemolytic anemia in childrenBlood, 2003
- High-dose cyclophosphamide for refractory autoimmune hemolytic anemiaBlood, 2002
- Autoimmune hemolytic anemiaAmerican Journal of Hematology, 2002
- CONTROL OF STEROID‐RESISTANT AUTOIMMUNE HAEMOLYTIC ANAEMIA BY CYCLOSPORINEBritish Journal of Haematology, 1990