Characterization of Nucleic Acids by Nanopore Analysis
- 27 September 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 35 (10), 817-825
- https://doi.org/10.1021/ar000138m
Abstract
Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.Keywords
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