Stimulation-produced analgesia and its cross-tolerance between dorsal and ventral PAG loci
- 1 June 1990
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain
- Vol. 41 (3), 347-352
- https://doi.org/10.1016/0304-3959(90)90011-2
Abstract
This study explored the development of tolerance to brain stimulation-produced analgesia in both dorsal and ventral periaqueductal gray (PAG) sites and the development of cross-tolerance between naloxone-reversible and non-reversible sites. Cross-tolerance was produced from non-naloxone-reversible sites to naloxone-reversible sites (NNR-NR) and from naloxone-reversible sites to non-naloxone-reversible sites (NR-NNR). The following conclusions can be drawn from the present study: (1) the descending pain inhibitory systems within the PAG do not operate in isolation of each other since cross-tolerance to chronic stimulation can be produced between systems: (2) the interaction between the two systems is apparently bi-directional in that cross-tolerance was produced from naloxone-reversible to non-reversible sites and vice versa; and (3) the interaction may be the result of a co-activation of opioid and non-opioid systems produced by electrical stimulation or by a co-utilization of a common neuronal substrate. It is speculated that serotonin is a neurotransmitter involved in the mechanism of convergence.This publication has 4 references indexed in Scilit:
- Activation of periaqueductal grey pools of β-endorphin by analgetic electrical stimulation in freely moving ratsBrain Research, 1987
- Cross-tolerance between two brainstem sites supporting stimulation-produced analgesiaBehavioral and Neural Biology, 1982
- The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: Further studies on the anatomy of pain modulationJournal of Comparative Neurology, 1979
- Morphine-induced and stimulation-produced analgesias at coincident periaqueductal central gray loci: Evaluation of analgesic congruence, tolerance, and cross-toleranceExperimental Neurology, 1977