Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review
Open Access
- 1 March 2013
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical and Translational Gastroenterology
- Vol. 4 (3), e32
- https://doi.org/10.1038/ctg.2013.3
Abstract
Deciding on whether the Helicobacter pylori test-and-treat strategy is an appropriate diagnostic–therapeutic approach for patients with dyspepsia invites a series of questions. The aim present article addresses the test-and-treat strategy and attempts to provide practical conclusions for the clinician who diagnoses and treats patients with dyspepsia. Bibliographical searches were performed in MEDLINE using the keywords Helicobacter pylori, test-and-treat, and dyspepsia. We focused mainly on data from randomized controlled trials (RCTs), systematic reviews, meta-analyses, cost-effectiveness analyses, and decision analyses. Several prospective studies and decision analyses support the use of the test-and-treat strategy, although we must be cautious when extrapolating the results from one geographical area to another. Many factors determine whether this strategy is appropriate in each particular area. The test-and-treat strategy will cure most cases of underlying peptic ulcer disease, prevent most potential cases of gastroduodenal disease, and yield symptomatic benefit in a minority of patients with functional dyspepsia. Future studies should be able to stratify dyspeptic patients according to their likelihood of improving after treatment of infection by H. pylori. The test-and-treat strategy will cure most cases of underlying peptic ulcer disease and prevent most potential cases of gastroduodenal disease. In addition, a minority of infected patients with functional dyspepsia will gain symptomatic benefit. Several prospective studies and decision analyses support the use of the test-and-treat strategy. The test-and-treat strategy is being reinforced by the accumulating data that support the increasingly accepted idea that “the only good H. pylori is a dead H. pylori”.Keywords
This publication has 205 references indexed in Scilit:
- The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinomaHistopathology, 2012
- Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trialThe Lancet, 2011
- Evaluation of a novel rapid one-step monoclonal chromatographic immunoassay for detection of Helicobacter pylori in stool from childrenEuropean Journal of Clinical Microbiology & Infectious Diseases, 2007
- Economic evaluation of a randomized trial comparinghelicobacter pylori test-and-treat and prompt endoscopy strategies for managing dyspepsia in a primary-care settingClinical Therapeutics, 2005
- Management of Barrett's esophagusJournal of Gastrointestinal Surgery, 2000
- Can Noninvasive Helicobacter pylori Testing Save Endoscopy?Endoscopy, 1997
- U. S. Householder survey of functional gastrointestinal disordersDigestive Diseases and Sciences, 1993
- Prevalence of Helicobacter pylori Infection and Histologic Gastritis in Asymptomatic PersonsNew England Journal of Medicine, 1989
- Decision AnalysisNew England Journal of Medicine, 1987
- The diagnosis of early gastric cancer: A survey of experience in the United States*Gastrointestinal Endoscopy, 1976