Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction
- 29 September 2010
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (21), 4988-4991
- https://doi.org/10.1021/ol101990d
Abstract
Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper(Ι)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits the reaction. Such functionalities of an alkyl chain allow a rapid CuAAC reaction of even a bulky alkyne, which has been difficult to perform under conventional conditions.Keywords
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