CXCL12 (SDF-1)/CXCR4 Pathway in Cancer
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Open Access
- 31 May 2010
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 16 (11), 2927-2931
- https://doi.org/10.1158/1078-0432.ccr-09-2329
Abstract
Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. CXCR4 is expressed on multiple cell types including lymphocytes, hematopoietic stem cells, endothelial and epithelial cells, and cancer cells. The CXCL12/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival. This pathway is a target for therapeutics that can block the CXCL12/CXCR4 interaction or inhibit downstream intracellular signaling. Clin Cancer Res; 16(11); 2927–31. ©2010 AACR.Keywords
This publication has 51 references indexed in Scilit:
- Chemokine CXC receptor 4–mediated glioma tumor tracking by bone marrow–derived neural progenitor/stem cellsMolecular Cancer Therapeutics, 2009
- Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100Blood, 2009
- CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growthMolecular Cancer Therapeutics, 2009
- WHIM syndrome: congenital immune deficiency diseaseCurrent Opinion in Hematology, 2009
- Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathwayBritish Journal of Cancer, 2008
- Chemokine signaling in cancer: One hump or two?Seminars in Cancer Biology, 2008
- SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemiaPublished by American Society of Hematology ,2008
- The Chemokine Receptor CXCR4 Strongly Promotes Neuroblastoma Primary Tumour and Metastatic Growth, but not InvasionPLOS ONE, 2007
- CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculatureProceedings of the National Academy of Sciences, 2007
- The SDF-1–CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesisTrends in Immunology, 2007