Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review
Top Cited Papers
- 6 October 2006
- Vol. 333 (7572), 782
- https://doi.org/10.1136/bmj.38973.444699.0b
Abstract
To compare the methodological quality and conclusions in Cochrane reviews with those in industry supported meta-analyses and other meta-analyses of the same drugs. Systematic review comparing pairs of meta-analyses that studied the same two drugs in the same disease and were published within two years of each other. Cochrane Database of Systematic Reviews (2003, issue 1), PubMed, and Embase. Two observers independently extracted data and used a validated scale to judge the methodological quality of the reviews. 175 of 1596 Cochrane reviews had a meta-analysis that compared two drugs. Twenty four meta-analyses that matched the Cochrane reviews were found: eight were industry supported, nine had undeclared support, and seven had no support or were supported by non-industry sources. On a 0-7 scale, the median quality score was 7 for Cochrane reviews and 3 for other reviews (P < 0.01). Compared with industry supported reviews and reviews with undeclared support, Cochrane reviews had more often considered the potential for bias in the review--for example, by describing the method of concealment of allocation and describing excluded patients or studies. The seven industry supported reviews that had conclusions recommended the experimental drug without reservations, compared with none of the Cochrane reviews (P = 0.02), although the estimated treatment effect was similar on average (z = 0.46, P = 0.64). Reviews with undeclared support and reviews with not for profit support or no support had conclusions that were similar in cautiousness to the Cochrane reviews. Industry supported reviews of drugs should be read with caution as they were less transparent, had few reservations about methodological limitations of the included trials, and had more favourable conclusions than the corresponding Cochrane reviews.Keywords
This publication has 30 references indexed in Scilit:
- Assessment of methodological quality of primary studies by systematic reviews: results of the metaquality cross sectional studyBMJ, 2005
- Risk of cardiovascular events and rofecoxib: cumulative meta-analysisThe Lancet, 2004
- Pharmaceutical industry sponsorship and research outcome and quality: systematic reviewBMJ, 2003
- How objective are systematic reviews? Differences between reviews on complementary medicineJournal of the Royal Society of Medicine, 2003
- Screening for breast cancer with mammographyPublished by Wiley ,2001
- Systematic reviews in health care: Assessing the quality of controlled clinical trialsBMJ, 2001
- Steroids and peptic ulcer: an end to the controversy?Journal of Internal Medicine, 1994
- Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.BMJ, 1993
- Validation of an index of the quality of review articlesJournal of Clinical Epidemiology, 1991
- Study of information submitted by drug companies to licensing authorities.BMJ, 1980