Low dose danazol in the treatment of the premenstrual syndrome
- 1 May 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Heart
- Vol. 67 (787), 450-454
- https://doi.org/10.1136/pgmj.67.787.450
Abstract
Summary: This double-blind, randomized, crossover study compared the efficacy and safety of danazol (100 mg twice daily) with matching placebo in the treatment of severe premenstrual syndrome. Nineteen patients were randomly allocated to receive danazol for 3 months followed by placebo, and 18 to receive treatment in the reverse order. Assessments of overall condition showed improvement to be statistically significantly more likely with danazol than with placebo (P<0.001) after 3 months' treatment. Furthermore, daily visual analogue scale assessments demonstrated statistically significantly better premenstrual scores with danazol in comparison to placebo for breast discomfort, irritability, depression, anxiety, mood swings, crying, depressed libido and abdominal swelling. It is concluded that danazol provides effective and generally well tolerated treatment for severe premenstrual syndrome.Keywords
This publication has 7 references indexed in Scilit:
- Treatment of the premenstrual syndrome: A double blind placebo controlled cross over study using danazolJournal of Obstetrics and Gynaecology, 1989
- A clinical trial using danazol for the treatment of premenstrual tensionBJOG: An International Journal of Obstetrics and Gynaecology, 1987
- The Premenstrual SyndromeThe New England Journal of Medicine, 1984
- Prospective assessment of menstrually related mood disordersAmerican Journal of Psychiatry, 1984
- Premenstrual Changes and Affective Disorders1Psychosomatic Medicine, 1981
- Premenstrual tension syndrome: The development of research diagnostic criteria and new rating scalesActa Psychiatrica Scandinavica, 1980
- Menstruation and PersonalityThe British Journal of Psychiatry, 1963