The effect of insulin resistance and exercise on the percentage of CD16+monocyte subset in obese individuals
- 30 March 2016
- journal article
- clinical trial
- Published by Wiley in Cell Biochemistry and Function
- Vol. 34 (4), 209-216
- https://doi.org/10.1002/cbf.3178
Abstract
Obesity is now considered to be an inflammatory condition associated with many pathological consequences, including insulin resistance. It is proposed that insulin resistance contributes to the aggravation of the inflammatory dysfunction in obesity. The effect of obesity on the percentage of monocytes was previously observed in class II and III obese individuals who presented other alterations in addition to insulin resistance. In this study we observed that insulin-resistant obese individuals, but not insulin-sensitive ones, had an increased percentage of CD14(+) CD16(+) monocytes. This fact shows that a dysfunction of the monocyte percentage in class I obese individuals is only seen when this condition is associated with insulin resistance.Keywords
Funding Information
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (APQ-02918-12, APQ-01621-10, APQ-581-11)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 477154/2011-5, CAPES PNPD 2455/2011)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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