Synthesis and antitumor activity of novel 6-aryl and 6-alkylpyrazolo[3,4-d]pyrimidin-4-one derivatives
- 30 November 2010
- journal article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 45 (11), 5286-5291
- https://doi.org/10.1016/j.ejmech.2010.08.048
Abstract
No abstract availableKeywords
This publication has 8 references indexed in Scilit:
- Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituentBioorganic & Medicinal Chemistry Letters, 2010
- Synthesis of some new pyrazolo[3,4-d]pyrimidine derivatives of expected anticancer and radioprotective activityEuropean Journal of Medicinal Chemistry, 2010
- Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitorsEuropean Journal of Medicinal Chemistry, 2008
- Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell lineEuropean Journal of Medicinal Chemistry, 2004
- Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent KinasesJournal of Medicinal Chemistry, 2004
- Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitorsEuropean Journal of Medicinal Chemistry, 2003
- New Colorimetric Cytotoxicity Assay for Anticancer-Drug ScreeningJNCI Journal of the National Cancer Institute, 1990
- Synthesis of pyrazolo[3,4‐d]pyrimidine derivatives using ketene dithioacetalsJournal of Heterocyclic Chemistry, 1990