Triad 1 induces apoptosis by p53 activation
- 10 March 2010
- journal article
- Published by Wiley in FEBS Letters
- Vol. 584 (8), 1565-1570
- https://doi.org/10.1016/j.febslet.2010.03.011
Abstract
Triad 1 (2 RING [really interesting new gene] fingers and DRIL [double RING finger linked] 1) is an E3 ligase that induces apoptosis and clonogenic inhibition in myeloid cells through Gfi-1 stabilization. Here we demonstrate that Triad 1 induces apoptosis in several cancer cell lines including MCF7, A549, U2OS, and HCT 116 p53 +/+ cells via its RING ligase activity. Interestingly, in these cancer cells, Triad 1-induced apoptosis is not mediated by Gfi-1 stabilization but is instead p53-dependent. Moreover, Triad 1 promotes transactivation of p53. These results suggest that Triad 1 can induce apoptosis through its ligase activity via p53 activation.Keywords
Funding Information
- Ministry of Education, Science, and Technology (20090081795, 20090077650, 20090078237)
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