Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Top Cited Papers
- 21 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (2), 101-117
- https://doi.org/10.1038/nri3369
Abstract
Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, they recognize self and foreign lipid antigens presented by CD1d in a conserved manner, but their activation can catalyse a spectrum of polarized immune responses. In this Review, we discuss recent advances in our understanding of the innate-like mechanisms underlying iNKT cell activation and describe how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iNKT cells in health and disease.Keywords
This publication has 171 references indexed in Scilit:
- Targeting iNKT cells for the treatment of sickle cell diseaseClinical Immunology, 2011
- Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humansClinical Immunology, 2011
- NKG2D performs two functions in invariant NKT cells: Direct TCR‐independent activation of NK‐like cytolysis and co‐stimulation of activation by CD1dEuropean Journal of Immunology, 2011
- A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T CellsImmunity, 2011
- A Molecular Basis for NKT Cell Recognition of CD1d-Self-AntigenImmunity, 2011
- Transcriptional regulation of NKT cell development and homeostasisCurrent Opinion in Immunology, 2010
- The A2aR adenosine receptor controls cytokine production in iNKT cellsEuropean Journal of Immunology, 2010
- The Transcription Factor PLZF Directs the Effector Program of the NKT Cell LineageImmunity, 2008
- CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune systemCurrent Opinion in Immunology, 2008
- Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage DevelopmentImmunity, 2007