Accuracy of fine‐needle aspiration cytology in the diagnosis of breast cancer a single‐center retrospective study from Turkey with cytohistological correlation in 733 cases
- 15 October 2015
- journal article
- research article
- Published by Wiley in Diagnostic Cytopathology
- Vol. 43 (12), 978-986
- https://doi.org/10.1002/dc.23380
Abstract
Background The triple test, i.e., cytology combined with clinical and radiological findings, is the goal for accurate assessment of palpable breast lesions. Because of the limitations of fine-needle aspiration cytology (FNAC), its utility has somewhat decreased nationwide. We have been using a combination of physical examination, radiological modalities, and FNAC for the diagnosis of palpable/nonpalpable breast mass lesions for the last 23 years. Our institutional experience of the last 10 years is presented here, using FNAC of breast lesions along with an analysis of the diagnostic accuracy. Methods 4956 breast aspirates in 4860 cases were collected from the computer database of Haydarpasa Numune Education and Research Hospital in Istanbul, Turkey. Most of the FNACs were performed under ultrasound guidance and FNAC procedures were performed by radiologists and pathologists who used 22 gauge needles. Cytological diagnoses were classified as “unsatisfactory”, “benign”, “malignant”, “atypical/probably benign”, “atypical/probably malignant”, and “atypical/NOS” (not otherwise specified) and were compared to the histopathological diagnoses obtained from core needle biopsy, lumpectomy or mastectomy to give an assessment of the diagnostic performance of FNAC in 733 aspirates. Results The sensitivity, specificity, accuracy, positive and negative predictive value, false positive, and false negative rates of FNAC were 98.02, 90.58, 95.97, 96.48, 94.54, 2.6, and 1.4%, respectively. Conclusions This study once again shows that FNAC is a reliable method for the initial evaluation and diagnosis of breast masses. In case of any suspicious conditions, FNAC, and core biopsy are considered complementary to one another. Diagn. Cytopathol. 2015;43:978–986.Keywords
This publication has 39 references indexed in Scilit:
- Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysisBMC Cancer, 2012
- Diagnosing breast lesions by fine needle aspiration cytology or core biopsy: which is better?Breast Cancer Research and Treatment, 2010
- A retrospective study of the diagnostic accuracy of fine‐needle aspiration for breast lesions and implications for future useDiagnostic Cytopathology, 2008
- Assessment of 1183 screen-detected, category 3B, circumscribed masses by cytology and core biopsy with long-term follow up dataBritish Journal of Cancer, 2008
- FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlationCytopathology, 2006
- Accuracy and Underestimation of Malignancy of Breast Core Needle Biopsy: the Florence Experience of Over 4000 Consecutive BiopsiesBreast Cancer Research and Treatment, 2006
- The Negative Predicative Value of Breast Fine-Needle Aspiration Biopsy: The Massachusetts General Hospital ExperienceThe Breast Journal, 2004
- Fine‐needle aspiration cytology vs. core biopsy in the diagnosis of breast lesionsDiagnostic Cytopathology, 2003
- What constitutes an adequate smear in fine-needle aspiration cytology of the breast?Cancer, 1997
- Triple approach in the diagnosis of dominant breast masses: Combined physical examination, mammography, and fine‐needle aspirationJournal of Surgical Oncology, 1994