TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP
Open Access
- 14 February 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (10), 1966-1974
- https://doi.org/10.1016/j.febslet.2010.02.028
Abstract
Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca2+ and Na+ channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca2+ release channels that respond to activation by the Ca2+ mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled.This publication has 53 references indexed in Scilit:
- Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal TraffickingCurrent Biology, 2010
- Calcium signaling via two-pore channels: local or global, that is the questionAmerican Journal of Physiology-Cell Physiology, 2010
- An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles*Published by Elsevier BV ,2010
- Essential requirement for two-pore channel 1 in NAADP-mediated calcium signalingThe Journal of cell biology, 2009
- Second Messenger Signaling: Multiple Receptors for NAADPCurrent Biology, 2009
- The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal storesPflügers Archiv - European Journal of Physiology, 2009
- The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channelsPflügers Archiv - European Journal of Physiology, 2009
- NAADP mobilizes calcium from acidic organelles through two-pore channelsNature, 2009
- NAADP induces pH changes in the lumen of acidic Ca2+ storesBiochemical Journal, 2007
- NAADP: A New Second Messenger for Glucose-Induced Ca2+ Responses in Clonal Pancreatic β CellsCurrent Biology, 2003