Generation of effector CD8+ T cells and their conversion to memory T cells
- 15 June 2010
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 236 (1), 151-166
- https://doi.org/10.1111/j.1600-065x.2010.00926.x
Abstract
Summary: Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector‐to‐memory transition, and mature into multipotent, functional memory T cells that self‐renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.Keywords
This publication has 150 references indexed in Scilit:
- Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T CellsImmunity, 2010
- Diversity in T Cell Memory: An Embarrassment of RichesImmunity, 2009
- Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription FactorsImmunity, 2009
- A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral InfectionImmunity, 2009
- Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell PropertiesImmunity, 2009
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage CommitmentImmunity, 2009
- Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell LineagesImmunity, 2008
- Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of AutoimmunityImmunity, 2008
- Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral InfectionImmunity, 2007
- Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription FactorImmunity, 2007