Voxel-Based Morphometry Reveals Gray Matter Network Atrophy in Refractory Medial Temporal Lobe Epilepsy

Abstract

Hippocampal sclerosis (HS) is the most common pathologic abnormality associated with medial temporal lobe epilepsy (MTLE).¹ This abnormality is defined by neuronal loss and gliosis involving the CA1, CA3, and CA4 hippocampal subregions and the granule cell layer of the dentate gyrus, with relative sparing of the CA2 subregion.² The use of hippocampal volumetric quantification through magnetic resonance imaging (MRI)^3,4 has been successfully applied to detect HS in vivo, and its reliability is based on this measurement’s correlation with neuronal counts of surgically resected hippocampal tissue.⁵