Intravenous Tigecycline Facilitates Cure of Severe Clostridium difficile Infection (CDI) After Failure of Standard Therapy: A Case Report and Literature Review of Tigecycline Use in CDI
Open Access
- 1 April 2016
- journal article
- review article
- Published by Oxford University Press (OUP) in Open Forum Infectious Diseases
- Vol. 3 (2), ofw094
- https://doi.org/10.1093/ofid/ofw094
Abstract
Standard treatment for severe Clostridium difficile infection (CDI) is oral vancomycin with metronidazole. After failure of this standard regimen, treatment becomes challenging. A young woman treated for septic shock developed CDI. Standard treatment failed and she was ineligible for fecal transplant. Addition of tigecycline to her regimen resulted in cure.This publication has 16 references indexed in Scilit:
- Tigecycline for severe Clostridium difficile infectionInternational Journal of Infectious Diseases, 2014
- Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficileJournal of Antimicrobial Chemotherapy, 2014
- RefractoryClostridium difficileInfection Successfully Treated with Tigecycline, Rifaximin, and VancomycinCase Reports in Medicine, 2012
- Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus VancomycinClinical Infectious Diseases, 2012
- Recurrent refractory Clostridium difficile colitis treated successfully with rifaximin and tigecycline: A case report and review of the literatureScandinavian Journal of Infectious Diseases, 2011
- Severe and refractory Clostridium difficile infection successfully treated with tigecycline and metronidazoleInternational Journal of Antimicrobial Agents, 2010
- Intravenous Tigecycline as Adjunctive or Alternative Therapy for Severe RefractoryClostridium difficileInfectionClinical Infectious Diseases, 2009
- In Vitro Activities of 15 Antimicrobial Agents against 110 Toxigenic Clostridium difficile Clinical Isolates Collected from 1983 to 2004Antimicrobial Agents and Chemotherapy, 2007
- Effect of Tigecycline on Normal Oropharyngeal and Intestinal MicrofloraAntimicrobial Agents and Chemotherapy, 2006
- Tigecycline: A Critical AnalysisClinical Infectious Diseases, 2006