Chromatin structure and the inheritance of epigenetic information

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Abstract
The chromatin landscape is a key aspect of epigenetic regulation in eukaryotes. Old histones are recycled during DNA replication, therefore providing a blueprint for the duplication of their modifications following DNA replication. Positive-feedback loops and cooperativity among chromatin-modifying complexes are crucial for the propagation of histone marks. The nuclear architecture and long-range interactions are likely to contribute to inheritance of epigenetic information. The concerted action of trans-acting factors and the chromatin landscape dictate the inheritance of epigenetic information.