Variability of the subthalamic nucleus: The case for direct MRI guided targeting
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in British Journal of Neurosurgery
- Vol. 21 (2), 197-200
- https://doi.org/10.1080/02688690701272240
Abstract
Because of concerns about direct visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI), many functional neurosurgeons continue to rely on atlas-based coordinates to reach this target. T2-weighted MRI does allow direct visualisation of the STN. In order to compare the coordinates of the target point within the visualised STN with those obtained from standard brain atlases, the preoperative stereotactic T2-weighted MRI used to implant 55 deep brain stimulation electrodes in the visualised STN of 29 consecutive patients with Parkinson's disease treated in two European centres were studied. The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus.Keywords
This publication has 8 references indexed in Scilit:
- Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgeryExperimental Neurology, 2006
- Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus proceduresSurgical Neurology, 2005
- Determining the position and size of the subthalamic nucleus based on magnetic resonance imaging results in patients with advanced Parkinson diseaseJournal of Neurosurgery, 2004
- Deep brain stimulation of the subthalamic nucleus in Parkinson's Disease 1993 – 2003: where are we 10 years on?British Journal of Neurosurgery, 2004
- A Quick and Universal Method for Stereotactic Visualization of the Subthalamic Nucleus before and after Implantation of Deep Brain Stimulation ElectrodesStereotactic and Functional Neurosurgery, 2003
- Results of chronic subthalamic nucleus stimulation for Parkinson’s disease: a 1-year follow-up studySurgical Neurology, 2002
- Stereotactic imaging of the pallidal target.Movement Disorders, 2002
- Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidanceJournal of Neurosurgery, 2000