Methylazoxymethanol Treatment of Fetal Rats Results in Abnormally Dense Noradrenergic Innervation of Neocortex
- 26 January 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 203 (4378), 369-371
- https://doi.org/10.1126/science.32620
Abstract
A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical gamma-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.This publication has 25 references indexed in Scilit:
- The distribution and orientation of noradrenergic fibers in neocortex of the rat: An immunofluorescence studyJournal of Comparative Neurology, 1978
- Cycle times of the neural epithelial cells of various types of neuron in the rat. An autoradiographic studyJournal of Comparative Neurology, 1974
- Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiationJournal of Comparative Neurology, 1974
- CATECHOLAMINES IN FETAL AND NEWBORN RAT BRAINJournal of Neurochemistry, 1973
- Kinetics of proliferation and latency between final cell division and onset of differentiation of cerebellar stellate and basket neuronsJournal of Comparative Neurology, 1973
- Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged x‐irradiation started at birthJournal of Comparative Neurology, 1972
- QUANTITATIVE CHANGES WITH AGE IN THE DNA CONTENT OF METHYLAZOXYMETHANOL‐INDUCED MICROENCEPHALIC RAT BRAIN1Journal of Neurochemistry, 1972
- Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in ratsJournal of Comparative Neurology, 1969
- Intellectual Deficit Associated with Transplacentally Induced Microcephaly in the RatScience, 1969
- Cell migrations to the isocortex in the ratThe Anatomical Record, 1968