Mechanisms of roof plate formation in the vertebrate CNS
- 1 October 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 5 (10), 808-812
- https://doi.org/10.1038/nrn1520
Abstract
The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.Keywords
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