Th1 and Th17 join forces for acute GVHD
- 3 November 2011
- journal article
- editorial
- Published by American Society of Hematology in Blood
- Vol. 118 (18), 4765-4767
- https://doi.org/10.1182/blood-2011-09-377325
Abstract
In this issue of Blood, Yu and colleagues demonstrate that combined targeted disruption of transcription factors T-bet and RORγt have defective differentiation of donor CD4+ T cells toward T helper 1 (Th1) and Th17, and ameliorated graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT).1This publication has 10 references indexed in Scilit:
- Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in miceBlood, 2011
- Stem cell mobilization with G-CSF induces type 17 differentiation and promotes sclerodermaBlood, 2010
- Altered Effector CD4+ T Cell Function in IL-21R−/− CD4+ T Cell-Mediated Graft-Versus-Host DiseaseThe Journal of Immunology, 2010
- T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host DiseaseTransplantation and Cellular Therapy, 2010
- Interleukin 17 Is Not Required for Autoimmune-Mediated Pathologic Damage during Chronic Graft-versus-Host DiseaseTransplantation and Cellular Therapy, 2010
- Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host diseaseBlood, 2009
- In vitro–differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestationsBlood, 2009
- IL-17 contributes to CD4-mediated graft-versus-host diseaseBlood, 2009
- Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host diseaseBlood, 2008
- IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantationJCI Insight, 1999