Combined Renal Sinus Fat and Perinephric Fat Renal Cell Carcinoma Invasion Has a Worse Prognosis Than Either Alone
- 1 July 2010
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 184 (1), 48-52
- https://doi.org/10.1016/j.juro.2010.03.010
Abstract
Recently groups reached differing conclusions when examining the prognostic significance of renal cell carcinoma perinephric and sinus fat invasion. We evaluated the impact of these pathological features on renal cell carcinoma survival and recurrence. We identified the pathological and clinical records of 110 patients treated surgically for renal cell carcinoma with extrarenal extension at our institution between 1997 and 2007. Patients with von Hippel-Lindau disease were excluded from study. We used Kaplan-Meier survival curves with the log rank statistic to evaluate differences between groups. Cox logistic regression analysis was used to control for metastatic disease, tumor size and renal vein involvement to determine differences among the groups. Patients with perinephric plus sinus fat invasion had worse cancer specific survival than those with perinephric or sinus fat invasion alone (p <0.005). There was no difference in cancer specific survival between those with sinus vs perinephric fat invasion (p = 0.248). On multivariate analysis perinephric plus sinus fat invasion was a significant prognostic factor for death from renal cell carcinoma compared to sinus fat invasion alone (p = 0.038). Patients with combined renal sinus and perinephric fat invasion had a worse prognosis than those with either alone. Considerations should be made to stage these cases accordingly.Keywords
This publication has 15 references indexed in Scilit:
- Does Renal Capsular Invasion Have Any Prognostic Value in Localized Renal Cell Carcinoma?Journal of Urology, 2008
- Proposal of an Improved Prognostic Classification for pT3 Renal Cell CarcinomaJournal of Urology, 2008
- Location of Extrarenal Tumor Extension Does Not Impact Survival of Patients With pT3a Renal Cell CarcinomaJournal of Urology, 2007
- Redefining pT3 renal cell carcinoma in the modern eraCancer, 2007
- Reevaluation of TNM staging of renal cortical tumors: Recurrence and survival for T1N0M0 and T3aN0M0 tumors are equivalentUrology, 2006
- IS RENAL SINUS FAT INVASION THE SAME AS PERINEPHRIC FAT INVASION FOR pT3a RENAL CELL CARCINOMA?Journal of Urology, 2005
- SHOULD DIRECT IPSILATERAL ADRENAL INVASION FROM RENAL CELL CARCINOMA BE CLASSIFIED AS pT3a?Journal of Urology, 2005
- CANCER SPECIFIC SURVIVAL FOR PATIENTS WITH pT3 RENAL CELL CARCINOMA—CAN THE 2002 PRIMARY TUMOR CLASSIFICATION BE IMPROVED?Journal of Urology, 2005
- TNM T3a Renal Cell Carcinoma: Adrenal Gland Involvement is Not the Same as Renal Fat InvasionJournal of Urology, 2003
- Renal Sinus Involvement in Renal Cell CarcinomasThe American Journal of Surgical Pathology, 2000