Individual Characteristics Associated with PBDE Levels in U.S. Human Milk Samples
- 1 January 2010
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 118 (1), 155-160
- https://doi.org/10.1289/ehp.0900759
Abstract
Reported polybrominated diphenyl ether (PBDE) concentrations in human samples in the United States have been higher than in Europe and Asia. Little is known about factors that contribute to individual variability in body burden. In this large study we measured PBDE concentrations in human milk from the United States during 2004–2006. We assessed characteristics associated with concentrations in milk and change in milk concentration between 3 and 12 months postpartum. We analyzed 303 milk samples obtained 3 months postpartum for PBDEs. A second sample was analyzed for 83 women still lactating 12 months postpartum. PBDE concentrations in milk and variability by individual characteristics such as age, parity, and prepregnancy body mass index (BMI) were evaluated using generalized linear models. PBDE congeners BDEs 28, 47, 99, 100, and 153 were detected in > 70% of samples. BDE-47 concentrations were the highest, ranging from below the limit of detection to 1,430 ng/g lipid, with a median of 28 ng/g lipid. Concentrations of most individual PBDE congeners and the sum of BDEs 28, 47, 99, 100, and 153 (∑PBDE) were lower among mothers > 34 years of age compared with those 25–29 years of age and higher among mothers with high compared with normal BMI, after adjustment for other covariates. Parity was not associated with PBDE concentration. The change in ∑PBDE concentration in milk between 3 and 12 months postpartum was highly variable (median increase, 14%; interquartile range, −26% to 50%). PBDEs were detected in nearly all human milk samples, varying by maternal weight and age and over the course of breast-feeding.Keywords
This publication has 60 references indexed in Scilit:
- Diet Contributes Significantly to the Body Burden of PBDEs in the General U.S. PopulationEnvironmental Health Perspectives, 2009
- Persistent Organic Pollutant Residues in Human Fetal Liver and Placenta from Greater Montreal, Quebec: A Longitudinal Study from 1998 through 2006Environmental Health Perspectives, 2009
- Participant experiences in a breastmilk biomonitoring study: A qualitative assessmentEnvironmental Health, 2009
- Determinants of Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Polybrominated Diphenyl Ethers (PBDEs) in an Urban PopulationEnvironmental Health Perspectives, 2007
- Depuration of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) in Breast Milk from California First-Time Mothers (Primiparae)Environmental Health Perspectives, 2007
- Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardantsNeuroToxicology, 2007
- Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USAJournal of Environmental Monitoring, 2007
- Polybrominated Diphenyl Ethers (PBDEs) In U.S. Computers and Domestic Carpet Vacuuming: Possible Sources of Human ExposureJournal of Toxicology and Environmental Health, Part A, 2005
- Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individualsInternational Journal of Obesity, 2000
- ANALYSIS OF POLYBROMINATED DIPHENYL ETHERS IN SWEDISH HUMAN MILK. A TIME-RELATED TREND STUDY, 1972-1997Journal of Toxicology and Environmental Health, Part A, 1999