Animal collagenases: Specificity of action, and structures of the substrate cleavage site
- 1 November 1974
- journal article
- research article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 61 (2), 605-612
- https://doi.org/10.1016/0006-291x(74)91000-6
Abstract
Two highly purified animal collagenases, one derived from homogenates of the rabbit V2 ascites cell carcinoma growing in muscle and the second isolated from the media of tadpole tissue cultures cleaved isolated non helical α chains from chick and rat skin collagen, and the CNBr peptide CB7 from chick skin α1 chains at one, and the same peptide bond. Although two other Gly-Ile bonds exist elsewhere in the α1 chain they were not cleaved.Keywords
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