Neuroendocrine (Merkel Cell) Carcinomas of the Skin: An Ultrastructural Study of Nine Cases
- 1 January 1981
- journal article
- case report
- Published by Informa UK Limited in Ultrastructural Pathology
- Vol. 2 (1), 1-9
- https://doi.org/10.3109/01913128109031497
Abstract
Nine neuroendocrine tumors of the skin were examined by light and electron microscopy. The patients (7 males and 2 females) had an average age of 57 years. Seven tumors were located in the head and neck region. Light microscopic examination showed sheets of cells. In 4 cases, a tendency to form small groups of cells was observed. Contact with the epidermis was seen in only 2 cases. The dominant ultrastructural feature was the presence of cytoplasmic processes that contained membrane-bound granules 100–200 nm. Three tumors recurred locally, and in 7 patients, regional nodal metastases occurred. Three patients died of disseminated disease.Keywords
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