Mammalian polyamine metabolism and function
Open Access
- 14 July 2009
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 61 (9), 880-894
- https://doi.org/10.1002/iub.230
Abstract
Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism. © 2009 IUBMB IUBMB Life 61(9): 880–894, 2009This publication has 146 references indexed in Scilit:
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