The vitamin D receptor geneBsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women
- 1 January 2008
- journal article
- Published by Informa UK Limited in Gynecological Endocrinology
- Vol. 24 (9), 514-518
- https://doi.org/10.1080/09513590802302985
Abstract
Vitamin D could have a direct effect on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion. In recent years several polymorphisms in the gene encoding the vitamin D receptor (VDR), which are potent to alter the activity of VDR protein, have been described. The present study aimed to investigate the prevalence of the VDR BsmI polymorphism and its association with anthropometric and biochemical features of metabolic syndrome in postmenopausal women. We studied 351 randomly selected healthy postmenopausal women, with mean age of 55.43 +/- 2.75 years and mean body mass index (BMI) of 27.5 +/- 4.78 kg/m2, to evaluate the frequency of BsmI polymorphism (by restriction fragment length polymorphism-polymerase chain reaction) in the VDR gene and to find out whether there is an association between this polymorphism and BMI, total fat volume and visceral fat (as determined by total body dual-energy X-ray absorptiometry), blood pressure, lipid profile (total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides) glucose and fasting insulin in the whole group, as well as subgroups of obese and non-obese women. The prevalence of BsmI genotypes in the study group was 51.0% Bb, 37.3% bb and 11.7% BB. Genotype distribution did not differ from that expected under Hardy-Weinberg equilibrium conditions (chi2 = 2.95, p = 0.22). Apart from LDL-C levels (F = 3.46, p = 0.032), there were no significant differences in anthropometric or metabolic parameters between genotypes. The BsmI polymorphism in the VDR gene does not seem to predispose to obesity and insulin resistance, but the BB genotype is connected with an unfavorable lipid profile.Keywords
This publication has 22 references indexed in Scilit:
- 1α,25(OH)2Vitamin D3-Regulated Expression of the Eukaryotic GenomeNutrition Reviews, 2009
- Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association StudiesAmerican Journal of Epidemiology, 2006
- Allele-frequency determination of BsmI and FokI polymorphisms of the VDR gene by quantitative real-time PCR (QRT-PCR) in pooled genomic DNA samplesThe Journal of Steroid Biochemistry and Molecular Biology, 2004
- Vitamin D Receptor Gene Polymorphisms and Association with Type 2 Diabetes Mellitus in a Polish PopulationExperimental and Clinical Endocrinology & Diabetes, 2003
- Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians.Diabetes, 1998
- Structural Organization of the Human Vitamin D Receptor Chromosomal Gene and Its PromoterMolecular Endocrinology, 1997
- Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysisJournal of Bone and Mineral Research, 1996
- Relationship between calbindin-D28K levels in the A and B cells of the rat endocrine pancreas and the secretion of insulin and glucagon: influence of vitamin D3 deficiency and 1,25-dihydroxyvitamin D3Journal of Endocrinology, 1996
- Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London AsiansDiabetologia, 1995
- 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion.Endocrinology, 1994