Local Renin-Angiotensin System in the Reproductive System
Open Access
- 1 January 2013
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Endocrinology
- Vol. 4, 150
- https://doi.org/10.3389/fendo.2013.00150
Abstract
The renin–angiotensin system (RAS) is well known as regulator of electrolytes and blood pressure. Besides this function, there are numerous studies supporting the idea of a local tissue RAS. This system controls the local activity of the different RAS family members, especially of the functional proteins Angiotensin II and Angiotensin (1-7). Those antagonistically acting proteins have been described to be expressed in different organ systems including the human reproductive tract. Therefore, this local RAS has been suspected to be involved in the control and regulation of physiological and pathological conditions in the female reproduction tract. This review of the available literature summarizes the physiological influence of the RAS on the follicular development, ovarian angiogenesis and placental- and uterine function. In addition, in the second part the role of the RAS concerning ovarian- and endometrial cancer becomes elucidated. This section includes possible novel therapeutic strategies via inhibition of RAS-mediated tumor growth and angiogenesis. Looking at a very complex system of agonistic and antagonistic tissue factors, it may be supposed that the RAS in the female reproduction tract will be of rising scientific interest in the upcoming years.This publication has 86 references indexed in Scilit:
- Serum agonistic autoantibodies against type-1 angiotensin II receptor titer in patients with epithelial ovarian cancer: a potential role in tumor cell migration and angiogenesisJournal of Ovarian Research, 2013
- Expression of the Renin-Angiotensin System in a Human Placental Cell LineClinical Medicine & Research, 2012
- Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advancesReproduction, 2012
- Gonadotropin Stimulation Increases the Expression of Angiotensin-(1–7) and Mas Receptor in the Rat OvaryReproductive Sciences, 2009
- The Uterine Placental Bed Renin-Angiotensin System in Normal and Preeclamptic PregnancyEndocrinology, 2009
- The Vasoactive Peptide Angiotensin-(1–7), Its Receptor Mas and the Angiotensin-converting Enzyme Type 2 are Expressed in the Human EndometriumReproductive Sciences, 2009
- Review: Systemic and uteroplacental renin—angiotensin system in normal and pre-eclamptic pregnanciesTherapeutic Advances in Cardiovascular Disease, 2008
- Activation of Local Chorionic Villi Angiotensin II Levels But Not Angiotensin (1-7) in PreeclampsiaHypertension, 2008
- Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in PreeclampsiaHypertension, 2007
- Characterization of Angiotensin II Receptor Type 2 during Differentiation and Apoptosis of Rat Ovarian Cultured Granulosa CellsBiochemical and Biophysical Research Communications, 1995