Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI
- 29 March 2005
- journal article
- case report
- Published by Wiley in Medical Physics
- Vol. 32 (4), 1128-1139
- https://doi.org/10.1118/1.1869612
Abstract
We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.Keywords
This publication has 59 references indexed in Scilit:
- Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case studyJournal of Biomedical Optics, 2004
- Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopyJournal of Biomedical Optics, 2004
- Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat during Focal IschemiaJournal of Cerebral Blood Flow & Metabolism, 2003
- Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breastEuropean Journal of Surgical Oncology, 2001
- Imaging the body with diffuse optical tomographyIEEE Signal Processing Magazine, 2001
- A gradient-based optimisation scheme for optical tomographyOptics Express, 1998
- Physiological and Pathological Factors of Human Breast Disease That Can Influence Optical DiagnosisaAnnals of the New York Academy of Sciences, 1998
- Staging of symptomatic primary breast cancer with MR imaging.American Journal of Roentgenology, 1997
- Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantomsApplied Optics, 1997
- Problems in evaluating response of primary breast cancer to systemic therapyBreast Cancer Research and Treatment, 1984